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团队成员

王文元

学历:博士研究生
职称:研究员
邮箱:wywang@sioc.ac.cn
电话:021-68582379
地址:上海市浦东新区海科路100号

简介

2013.9-至今 中国科学院生物与化学交叉研究中心 研究员、课题组长
2008-2013 麻省理工学院Picower 学习记忆研究中心 博士后、研究科学家
2006-2007 美国Salk生物研究所 博士后
1999-2005 中国科学院上海生命科学研究院,上海生理研究所,神经生物学国家重点实验室 博士
1994-1999 甘肃中医学院 学士

研究方向

本实验室将主要以小鼠和IPS cells为疾病模型,结合遗传学,动物行为学, 分子生物学,生物信息学,电生理和化学生物学等研究手段对重大的神经系统疾病脊髓侧索硬化症和前额颞叶痴呆症进行分子机制和致病机理研究,并积极探索可行的治疗方案和手段。

代表论文

1.Wang WY, Pan L, Su S, Quinn E, Sasaki M, Jimenez J, Brown R Jr, Hayward LJ, Huang EJ, Tsai LH (2013). Interaction of FUS and HDAC1 regulations DNA damage response and repair in neurons. Nature Neurosci, doi: 10.1038/nn.3514


2.Wang WY, Kwon E, Tsai LH (2012). microRNAs in Learning, Memory and neurological disorders. Learning and Memory, 19: 259-368.


3.Graff J, Guan JS, Rei D, Wang WY, Hennig K, Nieland TJF, Fass DM, Kao PF, Tsai LH (2012) An epigenetic blockade of cognitive functions in the neurodegenerative brain. Nature 483, 222-226.


4.Kwon E, Wang WY & Li-Huei Tsai (2011). Validation of schizophrenia associated genes CSMD1, C10orf26, CACNA1C, and TCF4 as miR-137 targets. Molecular Psychiatry, doi: 10.1038/mp.2011.170


5.Shen B, Xiang Z., Miller B., Louie G., Wang WY, Noel J.P., Gage FG. and Wang L (2011). Genetically Encoding Unnatural Amino Acids in Neural Stem Cells and Optically Reporting Voltage-sensitive Domain Changes in Differentiated Neurons. Stem Cells, 29: 1231-1240


6.Gao J*, Wang WY*, Mao YW, Gräff J, Guan JS, Pan L, Mak G, Kim D, Su SC, Tsai LH (2010). A novel pathway regulates memory and plasticity via SIRT1 and miR-134. Nature. 466:1105-1109. (* Equal Contribution. Highlighted by Nature Neuroscience Review; Selected as EDITORS’ Choice of Science; recommended by F1000.)


7.Wang WY, Takimoto JK, Louie DV, Baiga TJ, Noel JP, Lee KF, Slesinger PA, Wang L (2007). Genetically encoding unnatural amino acids for cellular and neuronal studies. Nat Neurosci. 10: 1063-1072. (Reported by Economist as a Science &Technology breakthrough)


8.Parrish AR, Wang WY, Wang L (2006). Manipulating proteins for neuroscience. Curr Opin Neurobio 16: 585-592.


9.Liu X, Ying G, Wang WY, Dong J, Wang Y, Ni Z and Zhou CF (2005). Entorhinal deafferentation induces upregulation of SPARC in the mouse hippocampus. Mol. Brain Res. 141: 58-65.


10.Wang WY, J. H. Dong, X. Liu, Y. Wang, G. X. Ying and C. F. Zhou (2005). Vascular endothelial Growth factor and its receptor Flk-1 are expressed in the hippocampus following entorhinal deafferentation. Neuroscience 134: 1167-1178.

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