Research articles:

19.  Han, Y.#; Li, J.#; Xia, W.#; Li, Q.; Sun, Z.; Zeng, W.; Hu, Y.; Luk, K.C.; Liu, C.*; Xiang, S.*; He, Z.*, Fibril fuzzy coat is important for α-synuclein pathological transmission activity. Neuron 2025. PMID: 40215967.

18.  Wang, Q.#; Liu, Z.#; Wang, Y.; Liu, Y.; Chen, Y.; Zhang, S.; Zeng, W.; Li, D.; Yang, F.; He, Z.; Xiao, W.*; Liu, C.*; Wang, C.*, Quantitative chemoproteomics reveals dopamine's protective modification of Tau. Nat Chem Biol 2025. PMID: 39979588.

17.  Xu, H.*; Qiu, Q.; Hu, P.; Hoxha, K.; Jang, E.; O'Reilly, M.; Kim, C.; He, Z.; Marotta, N.; Changolkar, L.; Zhang, B.; Wu, H.; Schellenberg, G. D.; Kraemer, B.; Luk, K. C.; Lee, E. B.; Trojanowski, J. Q.; Brunden, K. R.; Lee, V. M.*, MSUT2 regulates tau spreading via adenosinergic signaling mediated ASAP1 pathway in neurons. Acta Neuropathol 2024, 147 (1), 55. PMID: 38472475.

16. Guo, R.; Liu, J.; Min, X.; Zeng, W.; Shan, B.; Zhang, M.; He, Z.; Zhang, Y.; He, K.; Yuan, J.; Xu, D.*, Reduction of DHHC5-mediated beclin 1 S-palmitoylation underlies autophagy decline in aging. Nat Struct Mol Biol 2024, 31 (2), 232-245. PMID: 38177673.

15.  Zhao X.#; Zeng W.#; Xu H.#; Sun Z.; Hu Y.; Peng B.; McBride, J.D.; Duan J.; Zhang B.; Kim S.J.; Zoll B.; Saito T.; Sasaguri H.; Saido T.C.; Ballatore C.; Yao H.; Wang Z.; Trojanowski J.Q.; Brunden K.R.; Lee V.M.Y.*; He Z.*, A microtubule stabilizer ameliorates protein pathogenesis and neurodegeneration in mouse models of repetitive traumatic brain injury. Science Translational Medicine 2023, PMID: 37703352.

14.    Zhang, S.#; Zhu, Y.#; Lu, J.#; Liu, Z.#; Lobato, A. G.; Zeng, W.; Liu, J.; Qiang, J.; Zeng, S.; Zhang, Y.; Liu, C.; Liu, J.; He, Z.; Zhai, R. G.*; Li, D.*, Specific binding of Hsp27 and phosphorylated Tau mitigates abnormal Tau aggregation-induced pathology. Elife 2022, PMID: 36048712.

13.    Xu, G.#; Li, Y.#; Zhang, S.#; Peng, H.#; Wang, Y.#; Li, D.; Jin, T.; He, Z.; Tong, Y.; Qi, C.; Wu, G.; Dong, K.; Gou, J.; Liu, Y.; Xiao, T.; Qu, J.; Li, L.*; Liu, L.*; Zhao, P.*; Zhang, Z.*; Yuan, J.*, SARS-CoV-2 promotes RIPK1 activation to facilitate viral propagation. Cell Res 2021, PMID: 34663909.

12.    Xu, D.#; Zhao, H.#; Jin, M.; Zhu, H.; Shan, B.; Geng, J.; Dziedzic, S. A.; Amin, P.; Mifflin, L.; Naito, M. G.; Najafov, A.; Xing, J.; Yan, L.; Liu, J.; Qin, Y.; Hu, X.; Wang, H.; Zhang, M.; Manuel, V. J.; Tan, L.; He, Z.; Sun, Z. J.; Lee, V. M. Y.; Wagner, G.; Yuan, J.*, Modulating TRADD to restore cellular homeostasis and inhibit apoptosis. Nature 2020, PMID: 32968279.

11.    Weitzman, S. A.; Narasimhan, S.; He, Z.; Changolkar, L.; McBride, J. D.; Zhang, B.; Schellenberg, G. D.; Trojanowski, J. Q.; Lee, V. M. Y.*, Insoluble Tau From Human FTDP-17 Cases Exhibit Unique Transmission Properties In Vivo. J Neuropathol Exp Neurol 2020, PMID: 32838419.

10.    He, Z.*; McBride, J. D.; Xu, H.; Changolkar, L.; Kim, S. J.; Zhang, B.; Narasimhan, S.; Gibbons, G. S.; Guo, J. L.; Kozak, M.; Schellenberg, G. D.; Trojanowski, J. Q.; Lee, V. M.*, Transmission of tauopathy strains is independent of their isoform composition. Nat Commun 2020, PMID: 31911587.

9.      Darwich, N. F.#; Phan, J. M.#; Kim, B.; Suh, E.; Papatriantafyllou, J. D.; Changolkar, L.; Nguyen, A. T.; O'Rourke, C. M.; He, Z.; Porta, S.; Gibbons, G. S.; Luk, K. C.; Papageorgiou, S. G.; Grossman, M.; Massimo, L.; Irwin, D. J.; McMillan, C. T.; Nasrallah, I. M.; Toro, C.; Aguirre, G. K.; Van Deerlin, V. M.; Lee, E. B.*, Autosomal dominant VCP hypomorph mutation impairs disaggregation of PHF-tau. Science 2020, PMID: 33004675.

8.      He, Z.; Guo, J. L.; McBride, J. D.; Narasimhan, S.; Kim, H.; Changolkar, L.; Zhang, B.; Gathagan, R. J.; Yue, C.; Dengler, C.; Stieber, A.; Nitla, M.; Coulter, D. A.; Abel, T.; Brunden, K. R.; Trojanowski, J. Q.; Lee, V. M.*, Amyloid-beta plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation. Nat Med 2018, PMID: 29200205.

7.      Narasimhan, S.; Guo, J. L.; Changolkar, L.; Stieber, A.; McBride, J. D.; Silva, L. V.; He, Z.; Zhang, B.; Gathagan, R. J.; Trojanowski, J. Q.; Lee, V. M. Y.*, Pathological Tau Strains from Human Brains Recapitulate the Diversity of Tauopathies in Nontransgenic Mouse Brain. J Neurosci 2017, PMID: 29054878.

6.      Guo, J. L.; Narasimhan, S.; Changolkar, L.; He, Z.; Stieber, A.; Zhang, B.; Gathagan, R. J.; Iba, M.; McBride, J. D.; Trojanowski, J. Q.; Lee, V. M.*, Unique pathological tau conformers from Alzheimer's brains transmit tau pathology in nontransgenic mice. J Exp Med 2016, PMID: 27810929.

5.      Wang, J.#; Lu, R.#; Yang, J.#; Li, H.; He, Z.; Jing, N.; Wang, X.; Wang, Y.*, TRPC6 specifically interacts with APP to inhibit its cleavage by gamma-secretase and reduce Abeta production. Nat Commun 2015, PMID: 26581893.

4.      He, Z.; Jia, C.; Feng, S.; Zhou, K.; Tai, Y.; Bai, X.; Wang, Y.*, TRPC5 channel is the mediator of neurotrophin-3 in regulating dendritic growth via CaMKIIalpha in rat hippocampal neurons. J Neurosci 2012, PMID: 22764246.

3.      Ding, X.#; He, Z.#; Zhou, K.#; Cheng, J.; Yao, H.; Lu, D.; Cai, R.; Jin, Y.; Dong, B.; Xu, Y.; Wang, Y.*, Essential role of TRPC6 channels in G2/M phase transition and development of human glioma. J Natl Cancer Inst 2010, PMID: 20554944.

2.      Shi, Y.#; Ding, X#.; He, Z.#; Zhou, K. C.; Wang, Q.; Wang, Y.*, Critical role of TRPC6 channels in G2 phase transition and the development of human oesophageal cancer. Gut 2009, PMID: 19651628.

1.      Tai, Y.; Feng, S.; Ge, R.; Du, W.; Zhang, X.; He, Z.; Wang, Y.*, TRPC6 channels promote dendritic growth via the CaMKIV-CREB pathway. J Cell Sci 2008, PMID: 18559891.

Review articles:

5.  Zhang, T.; Cong, L.*; Chen, B.*; He, Z.*; Li, G.*; Qin, Q.*, Editorial: Multimodal interventions in Alzheimer's disease: from basic research to clinical practice. Front Neurol 2023, 14, 1303733. PMID: 37928148.

4.      Han, Y.; He, Z.*, Concomitant protein pathogenesis in Parkinson's disease and perspective mechanisms. Front Aging Neurosci 2023, PMID: 37181621.

3.      He, Z.*, TRPC Channel Downstream Signaling Cascades. Adv Exp Med Biol 2017, PMID: 28508310.

2.      Feng, S.; He, Z.; Li, H.; Wang, Y.*, Ca(2+) signaling initiated by canonical transient receptor potential channels in dendritic development. Neurosci Bull 2015, PMID: 25732528.

1.      Ding, X.; He, Z.; Shi, Y.; Wang, Q.; Wang, Y.*, Targeting TRPC6 channels in oesophageal carcinoma growth. Expert Opin Ther Targets 2010, PMID: 20235901.

#,Equal contribution; *, Corresponding author.