1997年9月-2002年7月 北京大学医学部医学学士学位
2002年9月-2007年12月 美国宾夕法尼亚大学神经科学博士学位
2008年1月-2008年5月 美国宾夕法尼亚大学博士后
2008年6月-2013年8月 美国霍华德休斯医学研究院助理研究员
2013年9月-至今 中国科学院生物与化学交叉研究中心研究员、课题组长

神经损伤和神经退行性疾病中的神经轴突退化变性坏死 (axon degeneration)。
神经轴突退化变性坏死是急性神经损伤如脊髓损伤和脑创伤以及很多与衰老相关的慢性神经退行性疾病如老年痴呆症(AD)、帕金森氏症(PD)、亨廷顿氏症(HD)、多发性硬化症(MS)、肌萎缩性脊髓侧索硬化症(ALS)等疾病中的常见病变。此外，糖尿病、青光眼和化疗引起的神经毒性也会导致继发性的神经轴突的退化变性坏死。由于人类的中枢神经在受损或变性坏死后再生能力极其有限，如何保护受损或患病的神经，预防、延缓、阻止乃至逆转神经轴突退化变性坏死是神经生物学领域的一个重要前沿课题。

方燕姗课题组运用全新的果蝇神经损伤活体动物模型结合分子遗传学、细胞生物学、生物化学、药物化学、高分辨率荧光成像、新一代测序技术、现代蛋白质组学和代谢组学等技术研究调控神经轴突退化变性坏死和促进神经再生的分子机制，并以此作为基础开发用于疾病诊断治疗的生物标志物和新型药物。

1. Li S, Qian B, Qiu F, Duan Y, Hu R, Cui J, Li W^# and FANG Y^#. (2026) “CDC5L functions as a transcriptional repressor to safeguard against overactive stress response and promote survival.” Genome Biology. (in press)

2. Long W, Li S, Wang Q, Yue W, Fu Y, Wang H, Jiang M, Hu X, Li Y, Cui J, Li A, Zhang Y, Zhang Z and FANG Y. (2025) “SCF^FBXO21-mediated ubiquitination and degradation of NMNAT2 regulates axon survival in nerve injury.” Journal of Cell Biology, 224(11):e202501072.

3. Wang Z, Li Z, Luan T, Cui G, Shu S, Liang Y, Zhang K, Xiao J, Yu W, Cui J, Li A^#, Peng G^# and FANG Y^#. (2024) “A spatiotemporal molecular atlas of mouse spinal cord injury identifies a distinct astrocyte subpopulation and therapeutic potential of IGFBP2.” Developmental Cell, 59(20):2787-2803.e8.

4. Shu S, Jiang M, Deng X, Yue W, Cao X, Zhang K, Wang Z, He H, Cui J, Wang Q, Qu K and FANG Y. (2023) “Heterochromatic silencing of immune-related genes in glia is required for BBB integrity and normal lifespan in Drosophila.” Aging Cell, 22:e13947.

5. Deng X, Sun X, Yue W, Duan Y, Hu R, Zhang K, Ni J, Cui J, Wang Q, Chen Y, Li A^# and FANG Y^#. (2022) “CHMP2B regulates TDP-43 phosphorylation and cytotoxicity independent of autophagy via CK1.” Journal of Cell Biology, 221(1): e202103033.

6. Zhang K, Jiang M and FANG Y. (2021) “The drama of Wallerian degeneration: the cast, crew and script.” Annual Review of Genetics, 55:93-113.

7. Gu J, Wang C, Hu R, Li Y, Zhang S, Sun Y, Wang Q, Li D, FANG Y^# and Liu C^#. (2021) “Hsp70 chaperones TDP-43 in dynamic, liquid-like phase and prevents it from amyloid aggregation.” Cell Research, 31(9):1024-1027.

8. Wang C, Duan Y, Duan G, Wang Q, Zhang K, Deng X, Qian B, Gu J, Ma Z, Zhang S, Guo L, Liu C^# and FANG Y^#. (2020) “Stress induces dynamic, cytotoxicity-antagonizing TDP-43 nuclear bodies via paraspeckle lncRNA NEAT1-mediated liquid-liquid phase separation.” Molecular Cell, 79(3):443-458.e7. (Highlighted with commentary by Malik and Barmada in Molecular Cell).

9. Duan Y, Du A, Gu J, Duan G, Wang C, Gui X, Ma Z, Qian B, Deng X, Zhang K, Sun L, Tian K, Zhang Y, Jiang H, Liu C^# and FANG Y^#. (2019) “PARylation regulates stress granule dynamics, phase separation, and neurotoxicity of disease-related RNA-binding proteins.” Cell Research, 29(3):233-247.

10. Wang H, Wang X, Zhang K, Wang Q, Cao X, Wang Z, Zhang S, Li A^# Liu K^# and FANG Y^#. (2019) “Rapid depletion of ESCRT protein Vps4 underlies injury-induced autophagic impediment and Wallerian degeneration.” Science Advances, 5(2):eaav4971.